One thing being under-reported in the post election aftermath is the number of state legislators that have gone republican. As of the 2010 election, 34 State Legislators are now of the GOP, more than they've ever had since the 1920's.
This is extremely significant for a number of reasons beyond the simple short term. Of course, the greatest stab in the heart for democrats lies on how these losses occured with the worst possible political timing. The fact that this landslide occurred on a census year could have Democrats in the wilderness for yet another decade.
Then you consider that consider that it takes 36 State Legislators to pass a Constitutional Amendment...